Molecular typing and characterization of Staphylococcus aureus isolates from burn wound infections in Fujian, China

Background Staphylococcus aureus ( S. ) is the most common causative agent of burn wound infection, that often leads to high morbidity and mortality. However, there not enough knowledge about molecular epidemiology antimicrobial susceptibility isolates from infections in Fujian, China. Methods Between 2016 2021, 90 were collected China, including 59 methicillin-resistant (MRSA) strains 31 methicillin-susceptible (MSSA) strains. These investigated for characteristics, virulence genes, biofilms, susceptibility. All genotyped by multilocus sequence typing (MLST), spa typing, agr SCC mec typing. Conventional PCR was performed detection genes. Biofilm formation capacity assessed tissue culture plate assay (TCP). The evaluated using dilution method. Results In total, 37 types (ST) 34 Staphylococcal protein A (including a new type named -t20720) identified based on (MLST) respectively. CC8-ST239-t030- I-SCC III (57.6%,34/59) CC7-ST7-t091- I (16.1%, 5/31) represented main clone MRSA MSSA isolates, Antibiotic testing significant difference resistance rates between ST239 non-ST239 p < 0.05). Twelve genes detected, which icaA icaD (both 100%), followed icaB icaC 96.7%), icaR (95.6%), lukED (81.1%), lukAB (62.2%), pvl (50%), hlgBC (26.7%), eta (4.4%). Moreover, , I, significantly correlated with severity less likely, compared carry lukAB, type, t20720, contains icaD, has strong biofilm ability. Conclusion CC7-ST-7-t091- prevalent signatures newly -t20720 isolate, carries wide range ability, requires special clinical attention.